Medically the evaluation by Darren Hein, PharmD — created by university of Illinois — updated on September 2, 2018


Mucinex and also Nyquil Cold & Flu room two common, over-the-counter remedies girlfriend can discover on your pharmacist’s shelf. Compare the symptoms the each medicine treats as well as their next effects, interactions, and warnings to view if one is a better option because that you.

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The main differences between these drugs space their active ingredients and also how those job-related to treat her symptoms.

Mucinex treats chest congestion. The main active ingredient is one expectorant referred to as guaifenesin. It functions by thinning the consistency of rubber in her air passages. This i m going up rubber in her chest so you deserve to cough the up and out.

NyQuil in the interim treats typical cold and also flu symptom such as fever, cough, sleep congestion, minor aches and also pains, headache, and also runny nose and also sneezing. The active ingredients space acetaminophen, dextromethorphan, and also doxylamine. This ingredients each work a small differently.

For example, paracetamol is a pains reliever and also fever reducer. It transforms the means your human body senses pain and regulates temperature. Dextromethorphan suppresses the signals in your brain that create your coughing reflex. Doxylamine, on the various other hand, blocks a problem in her body referred to as histamine. This substance causes allergy symptom such together itchy, watery eyes, runny nose, and itchy nose or throat. Together, these ingredients provide the relief girlfriend can gain from NyQuil.

The adhering to table summarizes the differences between Mucinex and NyQuil in ~ a glance.

Active ingredient(s)guaifenesinacetaminophen, dextromethorphan, doxylamine
Symptom(s) treatedchest congestionfever, cough, nasal congestion, minor aches and pains, headache, ill throat, runny nose, sneezing
Usagethroughout the dayat night
Formsextended-release dental tablet*, oral granulesoral fluid capsule, oral solution
Risk of interactionsnoyes
Risk of severe side effectsnoyes

*There is also an extra-strength form of this tablet, which includes twice as much of the active ingredient.

Forms and also dosage

You can use Mucinex transparent the day, but you frequently use NyQuil at night to help you sleep and let your body recover. The ingredient doxylamine in NyQuil additionally causes drowsiness to help you get rest.

Mucinex and NyQuil Cold & Flu are just for civilization 12 years and older. However, NyQuil has actually other assets that are specifically made for children ages 4 to 11 years.

The recommended dosage for each drug varies according to the form. Monitor the recommended dosage on the package of whatever kind you choose. Friend will should ask your medical professional for the correct dosage that NyQuil to offer to kids who room 4 come 11 years old.

Mucinex walk not have actually the risk of major side effects. However, the adhering to serious side results may be feasible with NyQuil:

vision problems, such together blurry visiondifficulty urinatingallergic reaction, with symptoms such as:red, skin or blistering skinrashhivesitchingswelling the the face, throat, tongue, lips, eyes, hands, or lower legsdifficulty breath or swallowing

If you have serious side effects, you must stop using the drug and call her doctor.


Drug interactions can increase or diminish the effect of the other medications. Interaction can also increase your risk of side effects. There room no known far-reaching interactions through guaifenesin, the energetic ingredient in Mucinex. However, all three active ingredients of NyQuil interact with other drugs.

Acetaminophen can connect with:

warfarinisoniazidcarbamazepine (Tegretol)phenobarbitalphenytoin (Dilantin)phenothiazines

Dextromethorphan can connect with:

isocarboxazidphenelzine (Nardil)selegilinetranylcypromine (Parnate)

Doxylamine can connect with:

isocarboxazidphenelzine selegilinetranylcyprominelinezolidopioids such as fentanyl, hydrocodone, methadone, and also morphine

You shouldn’t use Mucinex or NyQuil come treat a irreversible cough. Utilizing too much can reason harmful effects. You also shouldn’t use these commodities to treat symptoms of any kind of medical problem you have actually without talking to your medical professional first.

Other conditions

Other conditions you may have can impact how NyQuil functions for you. In part conditions, this drug deserve to be harmful. Ask a doctor before using NyQuil if friend have:

liver diseaseglaucomaurinating as result of enlarged prostate gland


Don’t usage Mucinex or NyQuil for longer than 7 days. If her symptoms aren’t relieved ~ a week, contact your doctor and also stop utilizing these drugs.

NyQuil includes acetaminophen, which can cause far-reaching liver damage if girlfriend overuse it. Taking an ext than 4 doses that NyQuil in 24 hrs can cause severe liver damage. Many over-the-counter drugs likewise contain acetaminophen. If you take it NyQuil, make sure you don’t take it with other drugs that contain acetaminophen. This will aid make sure you don’t accidentally usage too much of the drug.

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Mucinex and NyQuil room both products that relieve symptoms that the typical cold or flu. The symptom they treat space different. You can take Mucinex and also NyQuil together safely if you follow the encourage dosage for each drug. However, taking Mucinex at night with NyQuil can actually keep you from falling asleep. Mucinex will certainly loosen your mucus, i m sorry can reason you come wake as much as cough.

Deciding in between the two may simply mean picking the drug that treats the symptom that are bothering girlfriend the most. That course, you must never take any type of drug if you’re no sure exactly how to use it or if it’s ideal for you. Constantly talk come your medical professional if you have actually questions.